Control of infection was achieved after cimetidine was discontinued, and further studies [lo] in normal volunteers demonstrated that cimetidine given with keto- conazole resulted in
cimetidine + ketoconazole consider alternative or admin
The absorption of ketoconazole was reduced by more than half with Cimetidine, a consequence of its poor water solubility which is enhanced in acid
Cimetidine has been shown to inhibit various microsomal drug-metabolising enzymes in animal as well as human liver, most likely through the binding of the imidazole ring
You should not use antacids within 1 hour before or after taking cimetidine
Talk with your doctor if you are
This may be prevented by taking your statin dose and antacid dose at least two hours apart
Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and Nizatidine Download PDF
In the present study we investigated the influence of CYP2D and CYP3A on the stereoselective metabolism of metoprolol in rats
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Doses of ketoconazole of 2
Very important drug interactions are caused by inhibition of the hepatic microsomal enzyme cytochrome
Though other drugs may Cimetidine is a major P450 enzyme inhibitor, and decreases the clearance of many drugs: Chloramphenicol: risk of dose-dependent leukopenia
At the present time, a potentially significant alteration of absorption appears to exist with only ketoconazole, elemental iron, vitamin B12 (long-term therapy), and pancreatic enzyme supplements (increased activity)
2% and 20
Recommended dosages: cyclosporine, 5 mg/kg/day; ketoconazole, 10 mg/kg/day
Cimetidine appears to exacerbate the myelosuppressive effects of the nitrosoureas, and may also significantly alter the absorption of ketoconazole, and the clinical implication of these effects is uncertain
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