rhythmic movement of the muscles
Measure the dose with the dosing syringe that comes with the package
Are adverse effects related to dose or plasma clozapine levels? Most adverse effects are related to dose or plasma concentration
Clozapine is metabolised by CYP1A2 and CYP3A4 enzymes, which affect its serum levels and clinical effects
The reported proportions, however, vary considerably in different regions, e
There is a definite relationship between the dose of clozapine and the plasma clozapine and norclozapine concentrations (Table 1) although there is a wide (50-fold) variation
Influence of dose, cigarette smoking, age, sex, and metabolic activity on plasma clozapine concentrations: a predictive model and nomograms to aid clozapine
Our findings indicate that EEG slowing, obsessive-compulsive symptoms, heart rate variability, hyperinsulinemia, metabolic syndrome, and constipation correlate to
10
87 mg/l daily dose on tablets ( p = 0
I usually draw them 12 hours after the last dose (such as in the morning after the nightly dose) and several days after treatment begins
These data were analysed using ROC curves to determine the prediction performance of plasma clozapine levels for treatment response
The clozapine level at the point of optimal diagnostic benefit was 372 ng/mL; at Treatment must include monitoring of white blood cell count and absolute neutrophil count
The interaction of gender, age, smoking, other medication and side effects with plasma clozapine and metabolites are discussed
3
Indeed, a threshold for response of approximately 350 ng/mL is one of the more reliable findings in the literature on TDM in psychopharmacology, 9 and levels above at least 600 ng/mL (and certainly 1,000 ng/mL) are routinely associated with an increased risk of seizure
We included data on 294 individual participants from nine studies
Many factors may affect clozapine plasma levels including genetic variants of drug-metabolizing enzymes and transporting proteins, smoking habits, sex, age, concurrent use of other drugs, and food
Dizziness, confusion
Metabolism and pharmacokinetics of clozapine 8
ABCB1 is a transmembrane transporter that is expressed in excretory organs (kidneys and liver), in intestine mucosa and on the blood-brain barrier
Two cases of neutropenia were observed, of which one had to discontinue treatment with The primary interpretation of clozapine blood levels is done using the clozapine level itself ( see this SMI Adviser tip )
Background: It is unknown whether increasing the clozapine plasma level to 400, 750, or even 1000 ng/mL is a feasible and effective strategy in patients with treatment-resistant schizophrenia (TRS)
Clozapine is the most efficacious antipsychotic but is reserved for treatment-resistant schizophrenia owing to potentially serious side effects